Quoted from http://health.usnews.com/articles/health/diabetes/2009/07/07/5-risks-linked-to-diabetes-medications-like-lantus-avandia-actos.html
5 Risks Linked to Diabetes Medications Like Lantus, Avandia, Actos
Cancer, heart failure, fractures, and eye and liver problems among some diabetes drugs' possible risks
By January W. PaynePosted July 7, 2009For the 200 million diabetics worldwide, the past few years have brought some disturbing findings about risks that may be associated with certain diabetes drugs. Recent concerns that Avandia (rosiglitazone) might cause cardiovascular problems, for example, have led some experts to call for it to be pulled from the market, although it remains available today. And in late June, studies published online by the journal Diabetologia raised questions about a possible link between the diabetes medication Lantus (insulin glargine) and an increased risk of cancer.
The safety worries about these diabetes medications come from scientific studies of varying designs. Some of the research, like that on Lantus and cancer, is based on observational data, which is not always reliable. The concern about Avandia, on the other hand, comes from clinical trials, which are the gold standard of research, and meta-analyses.